MENOPAUSE IS ASSOCIATED WITH AN ALTERED GUT MICROBIOME AND ESTROBOLOME, WITH IMPLICATIONS FOR ADVERSE CARDIOMETABOLIC RISK IN THE HISPANIC COMMUNITY HEALTH STUDY/STUDY OF LATINOS.

Peters BA, Lin J, Qi Q, Usyk M, Isasi CR, Mossavar-Rahmani Y, Derby CA, Santoro N, Perreira KM, Daviglus ML, Kominiarek MA, Cai J, Knight R, Burk RD, Kaplan RC. Menopause Is Associated with an Altered Gut Microbiome and Estrobolome, with Implications for Adverse Cardiometabolic Risk in the Hispanic Community Health Study/Study of Latinos. mSystems. 2022 Jun 28;7(3):e0027322. doi: 10.1128/msystems.00273-22. Epub 2022 Apr 13. PMID: 35675542; PMCID: PMC9239235.

Analysis of the gut microbiome of a large set of Hispanic/Latinos in the United States revealed that post-menopausal Hispanic/Latino women had a gut microbiome more similar to that of men, and changes in gut microbiome due to menopause were associated with adverse cardiometabolic risks. These data suggest that the gut microbiome contributes to cardiometabolic health during menopause.

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FKBP51 CONTRIBUTES TO UTERINE LEIOMYOMA PATHOGENESIS BY INDUCING CELL PROLIFERATION AND EXTRACELLULAR MATRIX DEPOSITION.

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