Caradeux Bull J, Avila F, Vargas F, Fernandez B, Winkler C, Mondion M, Rojas I, Figueras F. Fetal growth velocity according to the mode of assisted conception. Fetal Diagn Ther. 2023 Jun 12. doi: 10.1159/000531451. Epub ahead of print. PMID: 37307807.

Luu TH, Kuhn K, Bradford AP, Wempe MF, Wittenburg L, Johnson RL, Carlson NE, Kumar TR, Polotsky AJ. Effects of pulsatile intravenous follicle-stimulating hormone treatment on ovarian function in women with obesity. Fertil Steril. 2023 Jun 3:S0015-0282(23)00588-5. doi: 10.1016/j.fertnstert.2023.05.170. Epub ahead of print. PMID: 37276947.

Sarkar P, New EP, Sprague RG, Stillman R, Widra E, Jahandideh S, Devine K, Imudia AN. Live birth per embryo transfer with next generation sequencing preimplantation genetic testing: an analysis of 26,107 cycles. Syst Biol Reprod Med. 2023 Jun 2:1-8. doi: 10.1080/19396368.2023.2208253. Epub ahead of print. PMID: 37267227.

Carlos Hernandez-Nieto, Joseph Lee, Tamar Alkon-Meadows, Luz Soto-Cossio, Benjamin Sandler, Tanmoy Mukherjee, Alan Copperman. Human Reproduction. 2023 Jun 1;38(6):1151-1161. doi: 10.1093/humrep/dead072. PMID: 37075318

Chelsea Canon, Carlos Hernandez-Nieto, Joseph A. Lee, Rose Marie Roth, Richard Slifkin, Christine Briton-Jones, Daniel Stein, Alan B. Copperman. Journal of Assisted Reproduction and Genetics (JARG). 2023 Jul;40(7):1765-1772. doi: 10.1007/s10815-023-02830-y. Epub 2023 May 25. PMID 37227570

Hariton E, Pavlovic Z, Fanton M, Jiang VS. Applications of artificial intelligence in ovarian stimulation: a tool for improving efficiency and outcomes. Fertil Steril. 2023 Jul;120(1):8-16. doi: 10.1016/j.fertnstert.2023.05.148. Epub 2023 May 19. PMID: 37211063.

Hariton E, Andrusier M, Fine E. Recurrent implantation failure: Are we throwing Hail Mary on Third Down? Fertil Steril. 2023 Jul;120(1):60. doi: 10.1016/j.fertnstert.2023.04.037. Epub 2023 May 3. PMID: 37142049.

Brännström M, Racowsky C, Richards EG, Flyckt R, Stillman RJ, O’Brien JE, Ryan GL, de Ziegler D. Absolute uterine infertility a cornelian dilemma: uterine transplantation or surrogacy? Fertil Steril. 2023 Jun;119(6):918-929. doi: 10.1016/j.fertnstert.2023.04.005. Epub 2023 Apr 8. PMID: 37037300.

Santoro N. A day in the life of a reproductive endocrinologist and infertilty subspecialist-integration or dissolution? Fertil Steril. 2023 Jul;120(1):44. doi: 10.1016/j.fertnstert.2023.03.016. Epub 2023 Mar 21. PMID: 36948445.

Santoro N. What’s up (or down) with lipids in menopause? Fertil Steril. 2023 Jun;119(6):1068. doi: 10.1016/j.fertnstert.2023.03.011. Epub 2023 Mar 17. PMID: 36934996.

Bortoletto P, Romanski PA, Petrozza JC, Pfeifer SM. Reproductive Surgery: Revisiting Its Origins and Role in the Modern Management of Fertility. Fertil Steril. 2023 Mar 2:S0015-0282(23)00164-4. doi: 10.1016/j.fertnstert.2023.02.031. Epub ahead of print. PMID: 36870592.

Poretsky L, Yeshua A, Cantor T, Avtanski D, Stojchevski R, Ziskovich K, Singer T. The effects of irisin and leptin on steroidogenic enzyme gene expression in human granulosa cells: In vitro studies. Metabol Open. 2023 Jan 13;17:100230. doi: 10.1016/j.metop.2023.100230. PMID: 36686605; PMCID: PMC9853360.

Adeleye AJ, Kawwass JF, Brauer A, Storment J, Patrizio P, Feinberg E. The mismatch in supply and demand: reproductive endocrinology and infertility workforce challenges and controversies. Fertil Steril. 2023 Jan 13:S0015-0282(23)00045-6. doi: 10.1016/j.fertnstert.2023.01.007. Epub ahead of print. PMID: 36642303.

New EP, Kodama S, Devine K, Jahandideh S, Imudia AN, Plosker SM. Live birth associated with peak serum estradiol levels in letrozole intrauterine insemination cycles. Fertil Steril. 2023 Jan 10:S0015-0282(23)00006-7. doi: 10.1016/j.fertnstert.2023.01.003. Epub ahead of print. PMID: 36634734.

Bardos J, Kwal J, Caswell W, Jahandideh S, Stratton M, Tucker M, DeCherney A, Devine K, Hill M, O’Brien JE. Reproductive genetics laboratory may impact euploid blastocyst and live birth rates: a comparison of 4 national laboratories’ PGT-A results from vitrified donor oocytes. Fertil Steril. 2023 Jan;119(1):29-35. doi: 10.1016/j.fertnstert.2022.10.010. Epub 2022 Nov 29. PMID: 36460523.

Santoro N. Reproductive endocrinology and infertility: the specialty with an ever changing alphabet soup. Fertil Steril. 2022 Dec;118(6):1035. doi: 10.1016/j.fertnstert.2022.10.012. Epub 2022 Nov 6. PMID: 36351855.

Dr. Nanette Santoro introduces Drs. Legro and DeCherney, and their Fertile Battle discussion topic: the application of genetics in the current and future Reproductive Endocrinology and Infertility practice.

Morris JM, Romanski PA, Harris BS. Mind the Gap – Isthmoceles and Infertility. Fertil Steril. 2022 Dec 7:S0015-0282(22)02093-3. doi: 10.1016/j.fertnstert.2022.12.006. Epub ahead of print. PMID: 36496081.

Prior studies have determined that a large isthmocele, an indentation of the myometrium at the site of incision from poor healing of the uterine tissue following Cesarean delivery, produces multiple unfavorable outcomes related to embryo implantation and development. This study enrolled women with unexplained infertility and prior Cesarean delivery resulting in a large isthmocele (residual overlying myometrial thickness of < 3 mm or residual myometrial thickness of <50% of adjacent myometrial tissue) and the primary outcome was endometrial thickness in the presence or absence of intrauterine fluid. Results from this study suggest that presence of an intrauterine fibroid had no significant effect on endometrial thickness (p=0.25), and that there exists a relationship between intrauterine fluid and a slightly longer duration of infertility (24 vs. 27 months; p=0.02).

Marsh P, Radif D, Rajpurkar P, Wang Z, Hariton E, Ribeiro S, Simbulan R, Kaing A, Lin W, Rajah A, Rabara F, Lungren M, Demirci U, Ng A, Rosen M. A proof of concept for a deep learning system that can aid embryologists in predicting blastocyst survival after thaw. Sci Rep. 2022 Dec 7;12(1):21119. doi: 10.1038/s41598-022-25062-z. PMID: 36477633; PMCID: PMC9729222.

Doyle N, Jahandideh S, Hill MJ, Widra EA, Levy M, Devine K. Effect of Timing by Endometrial Receptivity Testing vs Standard Timing of Frozen Embryo Transfer on Live Birth in Patients Undergoing In Vitro Fertilization: A Randomized Clinical Trial. JAMA. 2022 Dec 6;328(21):2117-2125. doi: 10.1001/jama.2022.20438. PMID: 36472596; PMCID: PMC9856480.

Frozen embryo transfers have gained popularity in recent years, and in 2020, 75% of fertility treatment cycles involved embryo cryopreservation. This randomized clinical trial was initiated to determine if the use of endometrial receptivity assay (ERA) to time frozen euploid blastocyst transfer increases the probability of live birth. Study participants were planning to undergo IVF, PGT-A testing, and frozen embryo transfer. Participants were aged 30 to 40 years old at the time of egg retrieval and likely to produce at least 1 euploid blastocyst. 767 patients were randomized to one of two study arms: use of ERA to time frozen embryo transfer, or standard timing for embryo transfer. Results from the study indicate that live birth rate is not improved with the use of ERA testing, compared to standard timing of frozen embryo transfer (58.5% vs. 61.9%, respectively; difference, -3.4% [95% CI, -10.3% to 3.5%]; rate ratio [RR], 0.95 [95% CI, 0.79 to 1.13]; P = 0.38). Similarly, clinical pregnancy rate was not improved with the use of ERA testing, compared to the control group (68.8% vs. 72.8%, respectively; difference, −4.0% [95% CI, −10.4% to 2.4%]; RR, 0.94 [95% CI, 0.80 to 1.12]; P = .25).

Santoro N. FSH: The Goldilocks Hormone, Too Little, Too Much, Just Right. Fertil Steril. 2022 Dec 5:S0015-0282(22)02058-1. doi: 10.1016/j.fertnstert.2022.12.003. Epub ahead of print. PMID: 36481419.

In this Views and Reviews, Dr. Nanette Santoro discusses the complexities related to FSH dosing during IVF. Recent research has supported the use of higher dosages of FSH during ovarian stimulation, but these high doses of FSH may affect tissues outside the desired gonadal targets. The current literature surrounding the topic suggests that there is still much to learn regarding FSH and ovarian stimulation.