Jaclyn Kwal, Jonah Bardos, Samad Jahandideh, Micah Hill, Alan DeCherney, Jeanne E. O’Brien, Michael Levy, Kate Devine, Jessica Kanter

Phillip A. Romanski, Melissa Stratton, Wayne Caswell, Kate Devine

Lauren Barrison, Melissa Stratton, Wayne Caswell, Kate Devine, Phillip A. Romanski

Papri Sarkar, Erika P. New, Rachel G. Sprague, Zoran Pavlovic, Samad Jahandideh, Kate Devine, Anthony N. Imudia

Bijan Morshedi, Seifeldin Sadek, Samad Jahandideh, Eric Widra, Kate Devine, Nicole Banks

Seth J. Barishansky, Jeanne O’Brien, Kathleen Devine, Angela K. Lawson

Eduardo Hariton, Kevin Ho, Eva Cui, Cora Chen, Jerrine R Morris, and Marcelle I Cedars

Aimee M Seungdamrong, Lubna Pal, Satu Kuokkamen, Harry Lieman, Robert A Wild, Fangbai Sun, Heping Zhand, Michael P Diamond, Richard S Legro, and Nanette Santoro

Victoria W. Fitz, Victoria W Fitz, Laura Grau, Savannah Mierau, Robin Green, Carol Derby, Ellen B Gold, Jan Leslie Shifren, Genevieve S Neal-Perry, Mary Sammel, Nanette Santoro

Alexandra Gannon, Janet Bruno-Gaston, Vipin A Vidyadharan, Shaji Chacko, Marta L Fiorotto, Juan Marini, Amy K Schutt, William Gibbons, Chellakkan Selvanesan Blesson, and Inka Didelija

Romanello JP, Sun B, Hill MJ, Singer T, O’Brien JE. The impact of the COVID-19 pandemic on gestational carriers. J Assist Reprod Genet. 2022 Oct;39(10):2365-2372. doi: 10.1007/s10815-022-02622-w. Epub 2022 Sep 24. PMID: 36152113; PMCID: PMC9510232.

The COVID-19 pandemic required ART practice centers to reevaluate and adapt their practice processes, having a particularly negative effect on the gestational carrier process. This article provides a comprehensive review of the changes made at the practice level to accommodate the required precautions during the COVID-19 pandemic for couples utilizing a gestational carrier, and gestational carriers themselves. Topics include the added psychological stress unto gestational carriers from the pandemic, changes to the gestational carrier process, patient safety during pregnancy and the pandemic, vaccination counseling, and the new normal in the REI practice.

Awadalla MS, Agarwal R, Ho JR, McGinnis LK, Ahmady A. Effect of trophectoderm biopsy for PGT-A on live birth rate per embryo in good prognosis patients. Arch Gynecol Obstet. 2022 Oct;306(4):1321-1327. doi: 10.1007/s00404-022-06679-x. Epub 2022 Jul 12. PMID: 35821525; PMCID: PMC9470687.

Punjani N, Bortoletto P, Romanski PA, Kashanian J, Spandorfer S. Advancing paternal age does not negatively impact fresh embryo transfer cycle outcomes. Reprod Biomed Online. 2022 Oct;45(4):737-744. doi: 10.1016/j.rbmo.2022.04.014. Epub 2022 Apr 29. PMID: 35840498.

Romanski PA, Bortoletto P, Pfeifer SM, Lindheim SR. An overview and video tutorial to the new interactive website for the American Society for Reproductive Medicine Müllerian Anomalies Classification 2021. Am J Obstet Gynecol. 2022 Oct;227(4):644-647. doi: 10.1016/j.ajog.2022.06.049. Epub 2022 Jun 28. PMID: 35777427. , Bortoletto P, Pfeifer SM, Lindheim SR. An overview and video tutorial to the new interactive website for the American Society for Reproductive Medicine Müllerian Anomalies Classification 2021. Am J Obstet Gynecol. 2022 Oct;227(4):644-647. doi: 10.1016/j.ajog.2022.06.049. Epub 2022 Jun 28. PMID: 35777427.

Siegel DR, Grau L, Sammel M, Nel-Themaaat L, Santoro N, Polotsky AJ. Anti-Müllerian Hormone and Follicle-Stimulating Hormone Are Poor Independent Predictors of Live Birth After Assisted Reproductive Technology. Reprod Sci. 2022 Oct 4. doi: 10.1007/s43032-022-01099-3. Epub ahead of print. PMID: 36194358.

Selter JH, Price TM, Harris BS. Fibroids in pregnancy: a growing or shrinking issue? Fertil Steril. 2022 Oct;118(4):666-667. doi: 10.1016/j.fertnstert.2022.08.001. Epub 2022 Sep 2. PMID: 36064663.

Dilday E, Gigg M, Hoyos L, Quinn M, Markovic D, Kroener L. Luteal phase support with progesterone does not improve pregnancy rates in patients undergoing ovarian stimulation with letrozole. Reprod Biomed Online. 2023 Jan;46(1):123-128. doi: 10.1016/j.rbmo.2022.09.012. Epub 2022 Sep 20. PMID: 36396533.

Supplemental progesterone is routinely used as luteal phase support in non-IVF fertility treatments, despite limited data to support its use. This was a retrospective cohort study that included 273 patients undergoing ovarian stimulation with letrozole paired with IUI or timed intercourse between January 2018 and October 2021. A total of 492 letrozole ovarian cycles were included. Ovulation stimulation protocol included baseline transvaginal ultrasound on cycle day 2 or 3, and letrozole (2.5, 5, or 7.5 mg) daily for five days. When given, vaginal progesterone (Prometrium, 200 mg) was initiated two days post-IUI or 4 days post-hCG trigger in timed intercourse cycles, twice or three times daily. Of these cycles, there was not a significant difference in multifollicular development between those who did and those who did not receive progesterone (P=0.337), as well as no difference in unadjusted clinical pregnancy rate between those who did and those who did not receive progesterone (P=0.645). Live birth rate and infant weight at delivery were similarly not significantly different between groups (P=0.599, 0.076, respectively).

Plowden TC, Mumford SL, Wild RA, Cedars MI, Steiner AZ, Franasiak JM, Diamond MP, Santoro N. Probability of Pregnancy With Mono vs Multiple Folliculogenesis in Women With Unexplained Infertility. J Endocr Soc. 2022 Sep 15;7(1):bvac142. doi: 10.1210/jendso/bvac142. PMID: 36447958; PMCID: PMC9692188.

This study was conducted as a secondary analysis of a randomized controlled trial that included 12 clinical sites across the US. The trial ‘Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation with 3 treatment arms: gonadotropins, clomiphene, or letrozole, combine with intrauterine insemination (AMIGOS trial)’ included women aged 18 to 40 years old with a normal uterine cavity, at least 1 patent fallopian tube, and male partners with ≥5 million total motile sperm. A total of 900 couples were enrolled. In the overall cohort, women with one mature follicle ≥16 mm at the time of hCG trigger were less likely to have a clinical pregnancy (RR, 0.70; 95% CI, 0.54-0.89) and live birth (RR, 0.67; 95% CI, 0.54-0.89) compared to women with ≥2 follicles larger than 16 mm. Comparable outcomes were observed when follicle size cutoff was ≥18 mm; women with one follicle were less likely to have a clinical pregnancy (RR, 0.77; 95% CI, 0.60-0.98) and live birth (RR, 0.75; 95% CI 0.58-0.97). When stratified by treatment modality, women using letrozole saw no difference in chance of live birth and follicle number, while women using clomiphene or gonadotropins were more likely to have a clinical pregnancy and live birth when having ≥2 follicles as opposed to one follicle.

Matevossian K, Rivelli A, Uhler ML. Fertility knowledge and views on egg freezing and family planning among surgical specialty trainees. AJOG Glob Rep. 2022 Sep 7;2(4):100096. doi: 10.1016/j.xagr.2022.100096. PMID: 36536848; PMCID: PMC9758326.

A survey was emailed to medical trainees across a broad range of medical specialties to gather information about US residents’ and fellows’ fertility knowledge and their views on family planning. The responses from those who completed the survey suggest that women physicians and Ob/Gyn trainees do not have greater knowledge of basic female fertility than males or those in other specialties. Female trainees were less likely to be married or have children and more likely to report postponing childbearing.

Romanski PA, Aluko A, Bortoletto P, Elias R, Rosenwaks Z. Age-specific blastocyst conversion rates in embryo cryopreservation cycles. Reprod Biomed Online. 2022 Sep;45(3):432-439. doi: 10.1016/j.rbmo.2022.04.006. Epub 2022 Apr 21. PMID: 35610153.